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Authors
Affiliations
1 Department of Pharmacology, Krupanidhi College of Pharmacy, Chikkabellandur, Carmalaram Post, Bangalore-560 035, IN
2 Department of Pharmaceutical Chemistry, Krupanidhi College of Pharmacy, Chikkabellandur, Carmalaram Post, Bangalore-560 035, IN
Source
Journal of Pharmaceutical Research, Vol 9, No 1 (2010), Pagination: 35-38
Abstract
The present study was undertaken to evaluate the cardioprotective effect of methanolic extract of Aegle marmoles leaves (AMLE) against isoproterenol (ISO) induced myocardial damage in rats. Rats of either sex were administered AMLE (100 and 500 mg/kg) for three weeks and propranolol (PRO, 10 mg/kg) for one week in their respective groups orally. Subsequently myocardium injury was induced by subcutaneous administration of isoproterenol (150 mg/kg) for two consecutive days. The influence of prophylactic treatment was analysed by quantification of biomarkers and antioxidants. The CK-MB activities were fallen in serum and raised in heart tissue of animals treated with low and high doses of AMLE as well as PRO compared to ISO control. However, low dose of AMLE did not demonstrate any significant change in serum and tissue LDH activity when compared to ISO control. Further, high and low doses of AMLE caused significant elevation in SOD and CAT activities compared to ISO control. Furthermore, TBARS level declined in heart tissues of animals treated with PRO and high doses of AMLE, whereas, low dose of AMLE was not equally potent. Hence it is concluded that the low dose of AMLE was less effective than the high dose of AMLE and PRO.
Keywords
Aegle marmoles, Antioxidants, Cardioprotection, Isoproterenol.
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